Recommended dose of Rubraca is 600 mg (two 300-mg tablets) taken orally twice daily with or without food 1. You can also report side effects directly via theBy reporting side effects you can help provide more information on the safety of this medicine.Keep this medicine out of the sight and reach of children.Do not use this medicine after the expiry date which is stated on the bottle and the carton after EXP.

This means that further evidence on this medicinal product is awaited. Rubraca 300 mg film-coated tablets . No effects on male and female fertility were observed in 3-month general toxicology studies in rats and dogs at exposures of 0.09 to 0.3 times the human AUC at the recommended dose. Pharmaceutical form. Patients should not start Rubraca treatment until they have recovered from haematological toxicities caused by previous chemotherapy (≤ CTCAE Grade 1). You may need medical help.If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.Like all medicines, this medicine can cause side effects, although not everybody gets them.Tell your doctor straight away if you notice any of the following side effects – you may need urgent medical treatment:If you get any side effects, talk to your doctor, pharmacist or nurse. It is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged. Rubraca is indicated as monotherapy treatment of adult patients with platinum sensitive, relapsed or progressive, BRCA mutated (germline and/or somatic), high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer, who have been treated with two or more prior lines of platinum based chemotherapy, and who are unable to tolerate further platinum based chemotherapy.Treatment with rucaparib should be initiated and supervised by a physician experienced in the use of anticancer medicinal products.There is no requirement for BRCA testing prior to using Rubraca for the maintenance treatment of adult patients with relapsed high-grade epithelial ovarian cancer (EOC), fallopian tube cancer (FTC), or primary peritoneal cancer (PPC) who are in a complete or partial response to platinum-based chemotherapy.Before taking Rubraca as treatment for relapsed or progressive EOC, FTC, or PPC, patients must have confirmation of deleterious germline or somatic mutations in the breast cancer 1 (BRCA1) or breast cancer 2 (BRCA2) gene using a validated test.
tBRCA includes all patients with a deleterious germline or somatic BRCA mutation, as determined by the CTA.In the ITT population, 38% of patients (141/375) in the rucaparib group and 35% of patients (66/189) in the placebo group had measurable disease at baseline.

Die Produktbewertungen beinhalten die persönlichen Erfahrungen unserer Kunden. Das Präparat ist in Form von Tabletten mit 200 mg, 250 mg oder 300 mg erhältlich. Rubraca blocks an enzyme that repairs damaged DNA in the cancer cells, resulting in their death.Rubraca is used to treat a type of cancer of the ovary. Rubraca must not be used during breast-feeding.Because of the potential for serious adverse reactions in breast-fed infants from rucaparib, breast-feeding is contraindicated during treatment with Rubraca and for 2 weeks after the final dose (see section 4.3). All 106 patients received rucaparib 600 mg twice daily. MwSt.Schnelle Lieferung in 1-2 Werktagen an Ihre Wunsch-Adresse. Bonus gilt nicht für E-Rezepte (papierlose Rezepte)Wir liefern versandkostenfrei, wenn Sie rezeptfreie Produkte ab 19 Euro Bestellwert kaufen oder wenn Sie ein Rezept einsenden. The mean age was 61 years (range: 36 to 85); most of the patients were white (80%); and all had an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Supportive care and institutional guidelines should be implemented for the management of low blood counts for the treatment of anaemia and neutropenia. Rubraca 200 mg film-coated tablet. Tablets (300 mg): yellow, oval, immediate-release, film-coated, debossed with “C3”. The primary tumour in most patients was ovarian (84%); most patients (95%) had serous histology and 4% of patients reported endometrioid histology.

Rubraca should be interrupted or dose reduced according to Table 1 (see section 4.2) and blood counts monitored weekly until recovery. A potential risk cannot be ruled out based on the safety margin observed. Intravenous administration of rucaparib in the rat and dog induced cardiac effects at a high CCarcinogenicity studies have not been performed with rucaparib. 4.5 Interaction with other medicinal products and other forms of interaction6.6 Special precautions for disposal and other handling9. Abdominal pain (combined terms abdominal pain, abdominal pain lower, abdominal pain upper) was reported in 40.1% of rucaparib treated patients, but was also very common (33%) in placebo patients, most likely associated with underlying disease.
Data suggest that rucaparib is a moderate inhibitor of CYP1A2, and a mild inhibitor of CYP2C9, CYP2C19, and CYP3A. For the platinum-resistant population (N=20), ORR by investigator review was 35.0% (95% CI [15.4, 59.2], with a complete response rate of 5.0%, and a partial response rate of 30.0%. Esta web usa cookies propias y de terceros que permiten ofrecer sus servicios. Der Arzt wird vor Beginn der Behandlung und danach monatlich ein Besteht der Verdacht einer Störung der Knochenmarksfunktion oder sogar von Blutkrebs, wird man die Patientin für Knochenmark- und Blutuntersuchungen an einen spezialisierten Arzt (Hämatologen) überweisen. Bonus gilt nicht für E-Rezepte (papierlose Rezepte)Wir liefern versandkostenfrei, wenn Sie rezeptfreie Produkte ab 19 Euro Bestellwert kaufen oder wenn Sie ein Rezept einsenden. The expiry date refers to the last day of that month.This medicine does not require any special storage conditions.Do not throw away any medicines via wastewater or household waste.


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