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Epub 2013 Jun 15.Expert Opin Drug Metab Toxicol.

Unable to load your delegates due to an error In this context, the interaction of pharmacological agents with mitochondria is an aspect of molecular biology that is too often disregarded, not only in terms of toxicology but also from a therapeutic point of view, especially considering the potential therapeutic applications related to the modulation of mitochondrial activity.At the mitochondrial level, there are several potential drug targets that can lead … Print 2018 Jan 1.Flanagan S, McKee EE, Das D, Tulkens PM, Hosako H, Fiedler-Kelly J, Passarell J, Radovsky A, Prokocimer P.Antimicrob Agents Chemother. Wellness Resources | 800-717-9355 | 952-929-4575 | 7155 Amundson Avenue, Edina, MN 55439 Mitochondrial damage caused by drugs, toxins, and nutrients deficiencies is an expanding issue and something that everyone needs to be aware of.

Cationic lipophilicity-based moieties (e. 5.2. Drug classes identified to cause mitochondrial toxicity are anti-diabetic drugs (thiazolidinediones, fibrates, biguanides), cholesterol lowering drugs (statins), anti-depressants (SARIs), pain medications (NSAIDs), certain antibiotics (fluroquinolones, macrolide), and anti-cancer drugs (kinase inhibitors and anthracyclins) [ 48 ].

Please enable it to take advantage of the complete set of features! Mitochondria play a central role in the life and death of cells. In this context, the interaction of pharmacological agents with mitochondria is an aspect of molecular biology that is too often disregarded, not only in terms of toxicology but also from a therapeutic point of view, especially considering the potential therapeutic applications related to the modulation of mitochondrial activity.At the mitochondrial level, there are several potential drug targets that can lead to toxicity, but only for few of them, a real clinical counterpart has been demonstrated.

2015 Jan;59(1):178-85. doi: 10.1128/AAC.03684-14. Mitochondria maintain homeostasis in the cell by interacting with reactive oxygen-nitrogen species and responding adequately to different stimuli. Recognizing the causes and effects of mitochondrial damage and then doing something about it puts you in the driver’s seat to keep your mitochondria healthy and help healthy aging.

Many age-related and seemingly unrelated disorders occur because of cumulative damage to mitochondria. 2005 Dec;1(4):655-69. doi: 10.1517/17425255.1.4.655.Curr Protoc Toxicol.

In addition to the medications directly impairing mitochondrial function, drugs can rob the body of several different nutrients. To avoid cationic... 5.3.

Many molecules are known inhibitors of the mitochondrial electron transport chain, interfering with one or more of the complexes in the respiratory chain. 2020 Jul 7;11:968. doi: 10.3389/fphar.2020.00968. 2007 Jul;293(1):C12-21. Epub 2014 Oct 20.Zhang Y, Cui Y, Zhu J, Li H, Mao J, Jin X, Wang X, Du Y, Lu J.Afr J Tradit Complement Altern Med. doi: 10.1128/MCB.00181-17. eCollection 2020.Singh MV, Kotla S, Le NT, Ae Ko K, Heo KS, Wang Y, Fujii Y, Thi Vu H, McBeath E, Thomas TN, Jin Gi Y, Tao Y, Medina JL, Taunton J, Carson N, Dogra V, Doyley MM, Tyrell A, Lu W, Qiu X, Stirpe NE, Gates KJ, Hurley C, Fujiwara K, Maggirwar SB, Schifitto G, Abe JI.Circulation.
2012 Dec 31;10(2):258-69. doi: 10.4314/ajtcam.v10i2.10. eCollection 2013. 2013 Oct 15;272(2):356-64. doi: 10.1016/j.taap.2013.06.005.

Harnessing the Power of the Mitochondria to Treat Human Diseases Mitochon Pharmaceuticals is a biotech company, formed in 2014, that focuses on developing drugs that target the mitochondria for a host of serious diseases with significant unmet medical needs. Springer


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