Arrowhead Pharmaceuticals develops medicines that treat intractable diseases by silencing the genes that cause them. Arrowhead Research Corp. ARWR 36.04 1.02 (2.75%). Arrowhead Pharmaceuticals develops medicines that treat intractable diseases by silencing the genes that cause them. The ECB decision is coming — here’s what to expect Lung disease is frequently treated with AAT augmentation therapy.

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A Phase 1 Single and Multiple Dose-Escalating Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Effect of ARO-AAT on Serum Alpha-1 Antitrypsin Levels in Normal Adult VolunteersAssessment of Changes in a Novel Histological Activity Scale in Response to ARO-AATA Pilot Open Label, Multi-dose, Phase 2 Study to Assess Changes in a Novel Histological Activity Scale in Response to ARO-AAT in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATD)Safety, Tolerability and Effect on Liver Histologic Parameters of ARO-AAT (SEQUOIA)SEQUOIA – A Placebo-Controlled, Multi-dose, Phase 2/3 Study to Determine the Safety, Tolerability and Effect on Liver Histologic Parameters in Response to ARO-AAT in Patients With Alpha-1 Antitrypsin Deficiency (AATD)Study of ARO-APOC3 in Healthy Volunteers, Hypertriglyceridemic Patients and Patients With Familial Chylomicronemia Syndrome (FCS)A Phase 1 Single and Multiple Dose-Escalating Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Effects of ARO-APOC3 in Adult Healthy Volunteers as Well as in Severely Hypertriglyceridemic Patients and Patients With Familial Chylomicronemia SyndromeStudy of ARO-ANG3 in Healthy Volunteers and in Dyslipidemic PatientsA Phase 1 Single and Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Effects of ARO-ANG3 in Adult Healthy Volunteers and in Dyslipidemic PatientsStudy of ARO-HSD in Healthy Volunteers and Patients With Non-Alcoholic Steatohepatitis (NASH) or Suspected NASHStudy of ARO-ENaC in Healthy Volunteers and in Patients With Cystic FibrosisStudy of ARO-HIF2 in Patients With Advanced Clear Cell Renal Cell CarcinomaStudy of ARO-HBV in Normal Adult Volunteers and Patients With Hepatitis B Virus (HBV)A Study of JNJ-73763989 in Healthy Japanese Adult ParticipantsA Study of Different Combination Regimens Including JNJ-73763989 and/or JNJ-56136379 for the Treatment of Chronic Hepatitis B Virus Infection (REEF-1)A Study of JNJ 73763989+JNJ 56136379+Nucleos(t)Ide Analog (NA) Regimen Compared to NA Alone in e Antigen Negative Virologically Suppressed Participants With Chronic Hepatitis B Virus Infection ARWR / Arrowhead Pharmaceuticals, Inc. / STATE STREET CORP Passive Investment. ARWR Stock Message Board for Investors. Find the latest Arrowhead Pharmaceuticals, Inc. (ARWR) stock discussion in Yahoo Finance's forum. The company believes that knocking down the hepatic production of apoC-III may result in reduced VLDL synthesis and assembly, enhanced breakdown of TRLs, and better clearance of VLDL and chylomicron remnants.Elevated triglyceride levels are an independent risk factor for cardiovascular disease. Reducing production of the inflammatory Z-AAT protein is expected to halt the progression of liver disease and potentially allow it to regenerate and repair.AATD is a rare genetic disorder associated with liver disease in children and adults and pulmonary disease in adults.

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